Toward understanding the role of methylation in aldosterone-sensitive Na+ transport

Proper endocrine regulation of Na+ reabsorption by renal principal cells is the primary means in mammals for maintaining blood pressure. Aldosterone i ncreases Na+ reabsorption by activating luminal Na+ channels; however, the signal transduction pathway of aldosterone is not fully understood Cellular methylation is necessary for aldosterone signaling to the luminal Na+ chan nel. We describe the enzymes, regulators, and effectors of aldosterone-medi ated methylation relevant to Na+ reabsorption.