Ca2+-activated Cl- channels: A newly emerging anion transport family

Authors
Fuller, CM Benos, DJ
Citation
Cm. Fuller et Dj. Benos, Ca2+-activated Cl- channels: A newly emerging anion transport family, NEWS PHYSL, 15, 2000, pp. 165-171
Citations number
15
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714 → ACNP
Volume
15
Year of publication
2000
Pages
165 - 171
Database
ISI
SICI code
0886-1714(200008)15:<165:CCCANE>2.0.ZU;2-5
Abstract
A new family of Cl- channels widely expressed in epithelia has been identif ied. These proteins are associated with Ca2+-sensifive conductive Cl- trans port when heterologously expressed This family may underlie the Ca2+-mediat ed Cl- conductance responsible for rescue of the cystic fibrosis knockout m ouse from significant airway disease.