Oxygen radicals as messengers in oxygen-dependent gene expression

Authors
Kietzmann, T Fandrey, J Acker, H
Citation
T. Kietzmann et al., Oxygen radicals as messengers in oxygen-dependent gene expression, NEWS PHYSL, 15, 2000, pp. 202-208
Citations number
15
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714 → ACNP
Volume
15
Year of publication
2000
Pages
202 - 208
Database
ISI
SICI code
0886-1714(200008)15:<202:ORAMIO>2.0.ZU;2-K
Abstract
Changes in ambient Po-2 need to be sensed to allow long-term adaptation of cellular functions via the regulation of gene activity. The generation of O H . from H2O2 in an iron-dependent perinuclear Fenton reaction for triggeri ng gene expression could be the key event in the O-2 signaling pathway.