1,4-hydrogen radical transfer as a new and versatile tool for the synthesis of enantiomerically pure 1,2,3-triols

Authors
Gulea, M Lopez-Romero, JM Fensterbank, L Malacria, M
Citation
M. Gulea et al., 1,4-hydrogen radical transfer as a new and versatile tool for the synthesis of enantiomerically pure 1,2,3-triols, ORG LETT, 2(17), 2000, pp. 2591-2594
Citations number
49
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
17
Year of publication
2000
Pages
2591 - 2594
Database
ISI
SICI code
1523-7060(20000824)2:17<2591:1RTAAN>2.0.ZU;2-O
Abstract
[GRAPHICS] 1,4-Hydrogen radical transfers can now be reliably envisaged in radical syn thetic chemistry as demonstrated by the formation of the cyano derivative I I from I. Due to related sequences involving this new translocation process , followed by a highly diastereoselective trapping of the resulting anomeri c radical, access to intriguing enantiopure 1,2,3-triols such as III is ava ilable.