Clinical outcome of pediatric patients on peritoneal dialysis under adequacy control

Clinical outcome under adequacy control was studied in 10 pediatric patient s under 5 pears and 11 patients over 5 years of age on continuous peritonea l dialysis (PD). Outcome was compared between the age groups and with our p revious results in patients under 5 years of age. Peritoneal equilibration test and 24-h dialysate collection were performed. Laboratory data, clinica l status, and diet were recorded. PD prescription was adjusted for these pa rameters. The mean weekly urea Kt/V was similar and stable in the two age g roups (3.1+/-0.6 vs. 3.2+/-0.4 at baseline). The mean weekly creatinine cle arance (C-Cr) was at baseline significantly lower in the younger age group (58.7+/-11.9 vs. 78.0+/-14.9 1/week per 1.73 m(2), P=0.004), but later simi lar. Urea Kt/V and C-Cr correlated significantly. Hematological and biochem ical parameters were stable, and catch-up growth was observed in 62% of the patients during 9 months of followup. The outcome for children under and o ver 5 years of are did not differ significantly. The clinical outcome in pa tients under 5 years of age improved under adequacy control, when compared with our previous results in patients of the same age. This suggests a posi tive effect of adequacy control on clinical outcome.