Bisbenzylisoquinoline alkaloids from Guatteria boliviana (Annonaceae)

Authors
Mahiou, V Roblot, F Fournet, A Hocquemiller, R
Citation
V. Mahiou et al., Bisbenzylisoquinoline alkaloids from Guatteria boliviana (Annonaceae), PHYTOCHEM, 54(7), 2000, pp. 709-716
Citations number
19
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
54
Issue
7
Year of publication
2000
Pages
709 - 716
Database
ISI
SICI code
0031-9422(200008)54:7<709:BAFGB(>2.0.ZU;2-P
Abstract
Together with known alkaloids, five new bisbenzylisoquinoline derivatives w ere isolated from the stem bark of Guatteria boliviana (Annonaceae), puerto galines-A 1 and -B 2, (+)-guatteboline 3, philogaline 4 and (-)-antioquine 5. Their structures were elucidated by spectrometric methods and their anti parasitic activity was evaluated in vitro on Leishmania sp., Trypanosoma cr uzi and Plasmodium falciparum. Their cytotoxic activity was also measured i n KB cell line. (C) 2000 Elsevier Science Ltd. All rights reserved.