1. Conflicting reports are available regarding the sensitivity of patients
with Dementia with Lewy bodies (DLB) to risperidone.
2. The authors studied a rare familial case of probable DLB, who developed
a documented episode of neuroleptic malignant syndrome (NMS) following the
exposure to risperidone. Previously, the patient had had an episode of NMS
on trifluoperazine.
3. The discontinuance of risperidone, in combination with a mild increase o
f dopaminergic therapy, led to a complete recovery in few days.
4. In patients with DLB, a continued vigilance for extrapyramidal side effe
cts, including NMS, would be advisable during the use of risperidone.