The L6 membrane proteins - A new four-transmembrane superfamily

Authors
Wright, MD Ni, J Rudy, GB
Citation
Md. Wright et al., The L6 membrane proteins - A new four-transmembrane superfamily, PROTEIN SCI, 9(8), 2000, pp. 1594-1600
Citations number
43
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PROTEIN SCIENCE
ISSN journal
09618368 → ACNP
Volume
9
Issue
8
Year of publication
2000
Pages
1594 - 1600
Database
ISI
SICI code
0961-8368(200008)9:8<1594:TLMP-A>2.0.ZU;2-8
Abstract
L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four tra nsmembrane domains. Previous sequence analysis led to their assignment as m embers of the tetraspanin superfamily. In this paper, we identify a new seq uence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.