P. Soucy et al., Use of malonate connectors in solid phase organic chemistry. Application to the synthesis of macrocarbocycles, SYNLETT, (8), 2000, pp. 1123-1126
The malonate unit is linked to solid supports and multistep syntheses of ma
crocycles are then carried out. Various reactions are studied on solid supp
orts and this investigation finally reveals that Solid Phase Organic Chemis
try (SPOC) is a reliable technology even for long sequences. The cyclizatio
ns using malonate anion S-N2 On allylic chlorides lead mostly to polymers a
nd indicate that pseudo-high dilution conditions are not found on solid sup
port.