The first synthesis of the bis(indole) marine alkaloid Rhopaladin D

Authors
Fresneda, PM Molina, P Sanz, MA
Citation
Pm. Fresneda et al., The first synthesis of the bis(indole) marine alkaloid Rhopaladin D, SYNLETT, (8), 2000, pp. 1190-1192
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
8
Year of publication
2000
Pages
1190 - 1192
Database
ISI
SICI code
0936-5214(200008):8<1190:TFSOTB>2.0.ZU;2-6
Abstract
The first synthesis (six steps) of the bis(indole) alkaloid Rhopaladin D is olated from the marine tunicate Rhopalaea sp. is described. The key step, c onstruction of the central imidazolinone ring, is based on the aza-Wittig r eaction of the iminophosphorane derived from the alpha-azido-beta-(3-indoly l)propenamide and indolyl-3-glyoxylyl chloride in the presence of polymer-s upported BEMP as a base.