Osteocalcin: A biochemical marker of bone formation in equine medicine

Osteocalcin is the most abundant non-collagenous bone protein. It is produc ed by osteoblasts and is accepted as a biochemical marker of bone formation . The authors summarize the current knowledge of physicochemical properties , biosynthesis and functional aspects of osteocalcin in various species. In addition, determinants of plasma/serum osteocalcin concentration in the eq uine species are described. Factors affecting blood osteocalcin concentrati on recognized in horses are: age, type of horse, circadian rhythm, season, administration of exogenous corticosteroids and general anesthesia. In comb ination with osteocalcin measurements the kidney function should always be evaluated because it is the main way for osteocalcin clearance. Serum/plasm a osteocalcin measurements are used in horses for training evaluation, for diagnostic purpose and to monitor the effect of a medical therapy on equine bone.