Sesquiterpene lactones from Centaurea achaia, a Greek endemic species: Antifungal activity

Authors
Skaltsa, H Lazari, D Garcia, B Pedro, JR Sokovic, M Constantinidis, T
Citation
H. Skaltsa et al., Sesquiterpene lactones from Centaurea achaia, a Greek endemic species: Antifungal activity, Z NATURFO C, 55(7-8), 2000, pp. 534-539
Citations number
29
Categorie Soggetti
Biochemistry & Biophysics
Journal title
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
ISSN journal
09395075 → ACNP
Volume
55
Issue
7-8
Year of publication
2000
Pages
534 - 539
Database
ISI
SICI code
0939-5075(200007/08)55:7-8<534:SLFCAA>2.0.ZU;2-4
Abstract
The aerial parts of Centaurea achaia afforded, in addition to several known sesquiterpene lactones and sesquiterpene hydroxyesters, a new germacranoli de and a new elemanolide. Their structures were determined as the 8 alpha-O -(4,5-dihydroxy-tigloyloxy) esters of salonitenolide and of 11,13-dihydrome litensin, respectively. The in vitro antifungal activity of most compounds was tested against nine fungal species using the micro-dilution method. All the tested compounds showed strong antifungal activity.