Ovarian micropapillary serous borderline tumors - Clinicopathologic features and outcome of seven surgically staged patients

We report the clinicopathologic findings for 7 patients with completely sta ged ovarian micropapillary serous borderline tumors (MSBTs) to further clar ify tremor behavior None of the MSBTs had microinvasion in the ovarian neop lasm. The MSBT pattern constituted 25% to almost all of the neoplasm. Four were bilateral, and 6 involved the ovarian surface. Five patients had perit oneal implants; 2 were invasive, and 3 were noninvasive MSBTs. Distribution of stages among patients was as follows: IA, 1; IC, 1; IIC, 2; IIIB, 2; an d IIIC, 1. Median follow-rep was 8.5 years. Four patients were alive and we ll at the last follow-up visit, including 1 patient with stage IIIC (lymph node metastases) disease who had noninvasive implants (12 years after surge ry). One patient who was free of disease died of complications of chemother apy and abdominal surgery. Two patients died of intra-abdominal neoplastic growth (stages IIC and IIIB) 5 and 9 years after surgery, respectively; bot h had invasive implants. Without invasive peritoneal implants, MSBTs seem t o behave as similar staged nonmicropapillary serous borderline tumors witho ut invasive peritoneal implants. With invasive peritoneal implants, they se em to behave as low-grade carcinomas. Pathologists should recognize MSBT as a neoplasm that can have adverse prognostic features, including invasive p eritoneal implants.