Synthesis and antimicrobial activity of some new 2-indolinone derived oximes and spiro-isoxazolines

The synthesis and spectral analysis of some new 1,3-dihydro-3-hydroxy-3-[2- hydroxyimino-2-(substituted phenyl)ethyl]-2H-indol-2-ones (21-32) and spiro [3H-indol-3,5'-(4' H)-isoxazol]-2(1H)-ones (33-44) are described. Sixteen o f the synthesized compounds were screened in vitro for their growth inhibit ory activity against thirteen species of microorganisms, viz, S. aureus, S. epidermidis, S. faecalis, B. subtilis, B. cereus, E. aerogens, E. coil, P. aeruginosa, P. vulgaris, A. baumonia, A. faecalis, C albicans and S. cervi cae. Most of the compounds exhibited significant antimicrobial activity esp ecially the oximes 28 and 29.