Synthesis and structure-activity relationships of novel compounds for the inhibition of TNF-alpha production

Authors
Park, JS Baik, KU Son, HJ Lee, JH Lee, SJ Cho, JY Park, J Yoo, ES Byun, YS Park, MH
Citation
Js. Park et al., Synthesis and structure-activity relationships of novel compounds for the inhibition of TNF-alpha production, ARCH PH RES, 23(4), 2000, pp. 332-337
Citations number
17
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
23
Issue
4
Year of publication
2000
Pages
332 - 337
Database
ISI
SICI code
0253-6269(200008)23:4<332:SASRON>2.0.ZU;2-I
Abstract
This study describes the synthesis, in vitro evaluation and molecular model ing study of novel compounds for the inhibition of TNF-alpha production. Am ong these compounds, 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone (9) was selected as a lead compound and its pyridine derivative 10 was mor e potent in activity and safer than rolipram.