Yh. Kim et al., Protection of the flowers of Prunus persica extract from ultraviolet B-induced damage of normal human keratinocytes, ARCH PH RES, 23(4), 2000, pp. 396-400
For an at-tempt to develop safe materials protecting solar ultraviolet (UV)
-induced skin damage, plant extracts were evaluated for their inhibitory ac
tivities of free radical generation and arachidonic acid/metabolites releas
e from UVB-irradiated normal human keratinocytes. From the results of these
screening procedures, the ethanol extract of the flowers of Prunus persica
(Ku-35) was selected for further study. It was found that Ku-35 (100-1,000
mu g/ml) inhibited the amount of C-14 arachidonic acid/metabolites release
from UVB-irradiated keratinocytes. It was also demonstrated that Ku-35 pos
sessed the protective activity against UV-induced cytotoxicity of keratinoc
ytes and fibroblasts. In addition, Ku-35 was revealed to protect UVB-induce
d erythema formation using guinea pigs in preliminary in vivo study. All th
ese results indicate that the flowers of P. persica extract may be benefici
al for protecting UV-induced skin damage when topically applied.