Study of the relationship between chemical structure and antimicrobial activity in a series of hydrazine-based coordination compounds

The dependence of antimicrobial activity on the structure of compounds is s tudied in a series of compounds based on hydrazine coordinated with ions of Cu(II), Ni(II) and Pd(II). The study has been carried out by means of the original electron-topological method developed earlier. A molecular fragmen t has been found that is only characteristic of biologically active compoun ds. Its spatial and electron parameters have been used for the quantitative assessment of the activity in view. The results obtained can be used for t he antimicrobial activity prediction in a series of compounds with similar structures.