Characterization of a novel member of the FGFR family, HrFGFR, in Halocynthia roretzi

Citation
S. Kamei et al., Characterization of a novel member of the FGFR family, HrFGFR, in Halocynthia roretzi, BIOC BIOP R, 275(2), 2000, pp. 503-508
Citations number
37
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
275
Issue
2
Year of publication
2000
Pages
503 - 508
Database
ISI
SICI code
0006-291X(20000828)275:2<503:COANMO>2.0.ZU;2-G
Abstract
The cDNA for a novel member of the FGFR family, named Ai FGFR, was isolated from a Halocynthia roretzi cDNA library prepared at the mid-tailbud stage. This cDNA was 3507b long, and the deduced amino acid sequence contained a motif characteristic of the vertebrate FGFRs. The existence of a single cop y of the FGFR homologue gene in H. roretzi was suggested by restriction sit e analysis of multiple clones. HrFGFR mRNA was expressed strongly in the po sterior region in the epidermis from the middle neurula stage. By contrast, Xenopus FGFR homologues are expressed in the anterior region and are known to induce anterior neural formation. A transition of the region expressing FGFR might have induced the more complicated brain or head formation chara cteristic of vertebrates. (C) 2000 Academic Press.