Phosphinic peptide inhibitors as tools in the study of the function of zinc metallopeptidases

Authors
Dive, V Lucet-Levannier, K Georgiadis, D Cotton, J Vassiliou, S Cuniasse, P Yiotakis, A
Citation
V. Dive et al., Phosphinic peptide inhibitors as tools in the study of the function of zinc metallopeptidases, BIOCH SOC T, 28, 2000, pp. 455-460
Citations number
22
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL SOCIETY TRANSACTIONS
ISSN journal
03005127 → ACNP
Volume
28
Year of publication
2000
Part
4
Pages
455 - 460
Database
ISI
SICI code
0300-5127(200008)28:<455:PPIATI>2.0.ZU;2-W
Abstract
The development of the combinatorial chemistry of phosphinic peptides has l ed to the discovery of both highly potent and selective inhibitors of vario us zinc metalloproteinases. Several properties of these compounds are revie wed, supporting the view that this class of inhibitors should represent use ful tools for probing several aspects of the function of this broad family of proteases in vivo.