Interaction of poly methyl vinyl ether/maleic anhydride-dimiristoyl phosphatidylcholine: a model bioadhesion study

The objective of this work is to study the interaction of a copolymer, poly methyl vinyl ether/maleic anhydride (PMV/MA) used in pharmaceutical dosage form and a phospholipid L-alpha-dimiristoyl phosphatidylcholine (DMPC) wit h the aim of developing a bioadhesive system. Glycerine is the plastifiant used to make PMV/MA insoluble. We have studied copolymer-plastifiant compat ibility with differential scanning calorimetry and we have studied the infl uence that the solvents produce on the copolymer by infrared spectroscopy. Monolayer experiments were carried out with a Wilhelmy-type surface balance . The purpose of these experiments is to obtain molecular information about interaction PMV/MA-glycerine system with DMPC. The results show that there are attractive forces and it is a spontaneous process. (C) 2000 Published by Elsevier Science Ltd.