Bias correction for segregation ratio estimation in human genetics

Authors
Citation
Yc. Yao et Jj. Tai, Bias correction for segregation ratio estimation in human genetics, BIOMETRICS, 56(3), 2000, pp. 795-800
Citations number
12
Categorie Soggetti
Biology,Multidisciplinary
Journal title
BIOMETRICS
ISSN journal
0006341X → ACNP
Volume
56
Issue
3
Year of publication
2000
Pages
795 - 800
Database
ISI
SICI code
0006-341X(200009)56:3<795:BCFSRE>2.0.ZU;2-O
Abstract
Segregation ratio estimation has long been important in human genetics. A s imple truncated binomial model is considered that assumes complete ascertai nment and a deterministic genotype-phenotype relationship. A simple but int uitively appealing estimator of the segregation ratio, previously proposed, is shown to have a negative bias. It is also shown that the bias of this e stimator can be largely reduced via a randomization device, resulting in a new estimator that has the same large-sample behavior but with a negligible bias (decaying at a geometric rate). Numerical results are given to show t he small-sample performance of this new estimator. An extension to incomple te ascertainment is also considered.