Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids

Authors
Njar, VCO Nnane, IP Brodie, AMH
Citation
Vco. Njar et al., Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids, BIOORG MED, 10(17), 2000, pp. 1905-1908
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
17
Year of publication
2000
Pages
1905 - 1908
Database
ISI
SICI code
0960-894X(20000904)10:17<1905:PIORAM>2.0.ZU;2-G
Abstract
Novel (+/-)-4-azolyl retinoic acid analogues 4, 5, 7 and 8 have been design ed and synthesized and have been shown to be powerful inhibitors of hamster microsomal all-trans-retinoic acid 4-hydroxylase enzyme(s). (+/-)-4-(1H-Im idazol-1-yl)retinoic acid (4) is the most potent inhibitor of this enzyme r eported to date. (C) 2000 Elsevier Science Ltd. All rights reserved.