Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha(1a)-receptor antagonists

Authors
Barrow, JC Glass, KL Selnick, HG Freidinger, RM Chang, RSL O'Malley, SS Woyden, C
Citation
Jc. Barrow et al., Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha(1a)-receptor antagonists, BIOORG MED, 10(17), 2000, pp. 1917-1920
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
17
Year of publication
2000
Pages
1917 - 1920
Database
ISI
SICI code
0960-894X(20000904)10:17<1917:PAEO1D>2.0.ZU;2-G
Abstract
Several 1,3-diaminocyclopentane linked alpha(1a)-receptor antagonists were prepared using a divergent chemical strategy that allows for rapid analysis of all stereochemical permutations for their effect on alpha(1)-receptor b inding. (C) 2000 Published by Elsevier Science Ltd.