Quantitative structure-intestinal permeability relationship of benzamidineanalogue thrombin inhibitor

Authors
Sugano, K Yoshida, S Takaku, M Haramura, M Saitoh, R Nabuchi, Y Ushio, H
Citation
K. Sugano et al., Quantitative structure-intestinal permeability relationship of benzamidineanalogue thrombin inhibitor, BIOORG MED, 10(17), 2000, pp. 1939-1942
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
17
Year of publication
2000
Pages
1939 - 1942
Database
ISI
SICI code
0960-894X(20000904)10:17<1939:QSPROB>2.0.ZU;2-R
Abstract
The intestinal permeability of benzamidine analogue thrombin inhibitor is c orrelated with molecular volume, lipophilicity (calculated log P and IAM co lumn capacity factor), hydrogen bond acidity/basicity and dipolarity. (C) 2 000 Elsevier Science Ltd. All rights reserved.