Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors

Authors
Egbertson, MS Bednar, B Askew, BC Bednar, RA Brashear, K Breslin, MJ Duggan, ME Fisher, TE Halczenko, W Hutchinson, JH Ihle, N Prugh, JD Wai, JS Gould, RJ Hartman, GD
Citation
Ms. Egbertson et al., Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors, BIOORG MED, 10(17), 2000, pp. 1943-1948
Citations number
35
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
17
Year of publication
2000
Pages
1943 - 1948
Database
ISI
SICI code
0960-894X(20000904)10:17<1943:NGRAP2>2.0.ZU;2-X
Abstract
Compound affinity for activated and resting GPIIb/IIIa receptors may differ , and comparison of those differences determines selectivity. Structural fe atures that influence selectivity are discussed. (C) 2000 Published by Else vier science Ltd.