Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide

Authors
Blagbrough, IS Geall, AJ David, SA
Citation
Is. Blagbrough et al., Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide, BIOORG MED, 10(17), 2000, pp. 1959-1962
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
17
Year of publication
2000
Pages
1959 - 1962
Database
ISI
SICI code
0960-894X(20000904)10:17<1959:LITTSB>2.0.ZU;2-5
Abstract
Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromi de displacement assay, bind with high affinity to bacterial lipopolysacchar ide and neutralise in vitro endotoxic activity as determined by Griess nitr ic oxide and TNF-alpha ELISA assays. (C) 2000 Elsevier Science Ltd. All rig hts reserved.