Potent, selective 3-pyridylethanolamine beta(3) adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore

Authors
Mathvink, RJ Tolman, JS Chitty, D Candelore, MR Cascieri, MA Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation
Rj. Mathvink et al., Potent, selective 3-pyridylethanolamine beta(3) adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore, BIOORG MED, 10(17), 2000, pp. 1971-1973
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
17
Year of publication
2000
Pages
1971 - 1973
Database
ISI
SICI code
0960-894X(20000904)10:17<1971:PS3BAR>2.0.ZU;2-N
Abstract
A series of thiazole benzenesulfonamide-substituted 3-pyridylethanolamines was prepared and evaluated for their human beta(3) adrenergic receptor agon ist activity. Incorporation of aryl and heteroaryl substitution in the 4-po sition of the thiazole ring resulted in a number of highly potent and selec tive beta(3) agonists. Results of preliminary in vivo evaluation of several of these compounds is described. (C) 2000 Elsevier Science Ltd. All rights reserved.