N-1-arylsulfonyl-N-2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines as novel calcimimetics acting on the calcium sensing receptor

Authors
Dauban, P Ferry, S Faure, H Ruat, M Dodd, RH
Citation
P. Dauban et al., N-1-arylsulfonyl-N-2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines as novel calcimimetics acting on the calcium sensing receptor, BIOORG MED, 10(17), 2000, pp. 2001-2004
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
17
Year of publication
2000
Pages
2001 - 2004
Database
ISI
SICI code
0960-894X(20000904)10:17<2001:NANC>2.0.ZU;2-Q
Abstract
The synthesis and calcimimetic properties of N-1-arylsulfonyl-N-2-(1-aryl)e thyl-3-phenylpropane-1,2-diamines are described. The most active compound o f the series (3n, used at 10 mu M) produced 97+/-11% of the maximal stimula tion of [H-3]IP production obtained by 10 mM Ca2+ in CHO cells expressing t he calcium sensing receptor (CaSR). This calcimimetic activity was due to a specific interaction of this compound with the CaSR. (C) 2000 Elsevier Sci ence Ltd. All rights reserved.