Use of proline bioisosteres in potential HIV protease inhibitors: Phenylalanine-2-thiophenoxy-3-pyrrolidinone: Synthesis and anti-HIV evaluation

Authors
Kraus, JL Bouygues, M Courcambeck, J Chermann, JC
Citation
Jl. Kraus et al., Use of proline bioisosteres in potential HIV protease inhibitors: Phenylalanine-2-thiophenoxy-3-pyrrolidinone: Synthesis and anti-HIV evaluation, BIOORG MED, 10(17), 2000, pp. 2023-2026
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
17
Year of publication
2000
Pages
2023 - 2026
Database
ISI
SICI code
0960-894X(20000904)10:17<2023:UOPBIP>2.0.ZU;2-P
Abstract
The synthesis of new phenylalanine-2-thiophenoxy-3-pyrrolidinones is descri bed. Anti-HIV recombinant protease assays and HIV infected cell culture ass ays (observation of syncytia) demonstrated the potent anti-HIV activity of this new class of pseudopeptides. (C) 2000 Published by Elsevier Science Lt d.