Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: Synthesis and dopamine receptor binding profiles

Authors
Einsiedel, J Thomas, C Hubner, H Gmeiner, P
Citation
J. Einsiedel et al., Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: Synthesis and dopamine receptor binding profiles, BIOORG MED, 10(17), 2000, pp. 2041-2044
Citations number
31
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
17
Year of publication
2000
Pages
2041 - 2044
Database
ISI
SICI code
0960-894X(20000904)10:17<2041:PAPABB>2.0.ZU;2-9
Abstract
Conformationally restricted benzamide bioisosteres were investigated when t he aminomethylpyrrolidine derivative 4o proved D3 as well as D4 binding pro perties which were comparable to those of the atypical neuroleptics sulpiri de and clozapine, respectively. (C) 2000 Elsevier Science Ltd. All rights r eserved.