mRNA expression of MT1-MMP, MMP-9, cathepsin K, and TRAP in highly enriched osteoclasts cultured on several matrix proteins and ivory surfaces

Authors
Uemura, T Liu, Y Kuboki, Y
Citation
T. Uemura et al., mRNA expression of MT1-MMP, MMP-9, cathepsin K, and TRAP in highly enriched osteoclasts cultured on several matrix proteins and ivory surfaces, BIOS BIOT B, 64(8), 2000, pp. 1771-1773
Citations number
16
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451 → ACNP
Volume
64
Issue
8
Year of publication
2000
Pages
1771 - 1773
Database
ISI
SICI code
0916-8451(200008)64:8<1771:MEOMMC>2.0.ZU;2-D
Abstract
We demonstrated that the transcriptional expression of MT1-MMP, MMP-9, cath epsin K, and TRAP in highly enriched osteoclasts were regulated by differen t matrix proteins that bind to integrin on osteoclast, such as collagen typ e I (Col), fibronectin (FN), vitronectin (VN), osteopontin (OPN), and ivory . Results suggested that the OPN-integrin alpha(v)beta(3) binding plays a m ore important role than CoI-alpha(2)beta(1) binding in the regulation of os teoclast activity.