M. Kubo et al., Increased serum levels of soluble vascular cell adhesion molecule-1 and soluble E-selectin in patients with polymyositis/dermatomyositis, BR J DERM, 143(2), 2000, pp. 392-398
Background Elevated levels of soluble vascular cell adhesion molecule-1 (sV
CBM-1) and soluble E-selectin (sE-selectin) have previously been reported i
n patients with various inflammatory diseases, but not in patients with pol
ymyositis/dermatsmyositis (PM/DM).
Objectives To determine serum levels and significance of sVCAM-1 and sE-sel
ectin in patients with PM/DM, Patients and methods Serum samples from 36 PM
/DM patients, 30 patients with systemic sclerosis and 25 healthy control su
bjects were examined using specific enzyme-linked immunosorbent assay syste
ms.
Results The serum levels of sVCAM-1 in the PM/DM patients were significantl
y higher than those in the healthy controls. The elevated serum sVCAM-1 lev
els were correlated with the values of elevated erythrocyte sedimentation r
ate and elevated serum hyaluronate levels in the PM/DM patients. The serum
sE-selectin levels in the PM/DM patients were also significantly higher tha
n those in the healthy controls. The elevated serum sE-selectin levels were
correlated with the incidence of elevated creatine kinase activities. The
concentrations of serum sE-selectin were correlated with the serum tissue i
nhibitor of metalloproteinase-l concentrations in the PM/DM patients (r = 0
.53).
Conclusions These results suggest that serum sVCAM-1 and sE-selectin levels
might be useful for detecting disease activity in patients with PM/DM.