Eosinophilic spongiosis in association with bullous pemphigoid and chroniclymphocytic leukaemia

We report the onset of an unusual blistering eruption following a diagnosis of B-cell chronic lymphocytic leukaemia (CLL). The histology consistently showed eosinophilic spongiosis, but the diagnosis of bullous pemphigoid was only confirmed after 13 years by repeated immunofluorescence studies. The occurrence of subepidermal blistering diseases in association with B-cell l ymphoproliferative disorders is rare; a recent study showed that the majori ty of these cases are epidermolysis bullosa acquisita, confirmed by immunol ogical studies. Only two cases of immunofluorescence-proven bullous pemphig oid in association with CLL have been previously reported.