Insulin-like growth factor-1 and breast cancer risk in postmenopausal African-American women

Citation
T. Agurs-collins et al., Insulin-like growth factor-1 and breast cancer risk in postmenopausal African-American women, CANCER DET, 24(3), 2000, pp. 199-206
Citations number
48
Categorie Soggetti
Oncology
Journal title
CANCER DETECTION AND PREVENTION
ISSN journal
0361090X → ACNP
Volume
24
Issue
3
Year of publication
2000
Pages
199 - 206
Database
ISI
SICI code
0361-090X(2000)24:3<199:IGFABC>2.0.ZU;2-H
Abstract
We explored the relationship between insulin-like growth factor-1 (IGF-1) c oncentrations and breast cancer risk. Also, we examined whether obesity, se x hormone-binding globulin (SHBG), and estradiol influenced IGF-1 concentra tions. A pilot study of 60 postmenopausal African-American women (30 cases and 30 controls was used. Plasma concentrations of IGF-1 were higher among the cases, as compared to the controls. A negative trend was seen for plasm a concentrations of IGF-1 and TNM (tumor-node-metastasis) stage and IGF-1 a nd body mass index. IGF-1 was found to be associated negatively with SHBG. After adjustment, plasma concentrations of IGF-1 remained significantly and positively associated with breast cancer risk (odds ratio, 1.183; 95% conf idence interval, 1.167-1.201). No significant associations for breast cance r risk were observed for estradiol, SHBG, and body mass index. Further rese arch with a larger sample is needed to clarify the relationships between ob esity and IGF-1 concentrations to breast cancer risk in this population.