Objective: The aims of this study were firstly to determine prevalence, fre
quency, and clinical significance of cerebral microemboli in an unselected
acute ischemic stroke population and secondly to examine how this informati
on may improve ischemic stroke subtype classification. Methods: We intended
to perform transcranial Doppler (TCD) microembolus monitorings of the midd
le cerebral artery (MCA) in the symptomatic hemisphere for 45 min in 120 co
nsecutive patients with internal carotid artery territory ischemia. The fir
st examination was performed within 72 h from start of symptoms and the sec
ond 5 +/- 1 days later. Platelet and coagulation system activation were mea
sured following TCD monitoring in 38 patients. The strokes were subtyped us
ing the TOAST classification criteria, and the patients' clinical status wa
s assessed at discharge using the Scandinavian Stroke Scale and the Barthel
Index. Results: Microembolus monitoring was technically possible in 83 (69
.2%) of the 120 patients. Thirty-two (26.6%) patients had an inadequate tem
poral bone acoustic window or were too restless to allow long-time monitori
ng. In 5 (4.2%) patients the relevant MCA was occluded. Twenty-two (26.5%)
of the 83 patients had microemboli despite the fact that over 90% were rece
iving an antiplatelet or an anticoagulant treatment. The mean frequency of
microemboli was 6.7 +/- 13.6 per 45 min. Microemboli were more prevalent in
assumed cardioembolic stroke than in other subtypes of ischemic stroke (p
= 0.047). We found no association between the presence of cerebral microemb
oli and the clinical outcome or the parameters for platelet or coagulation
system activation. The presence of microemboli was not associated with in-h
ospital deaths (p = 0.17), whereas MCA occlusion was (p = 0.01). Conclusion
s: Cerebral microemboli are frequent in unselected acute ischemic stroke pa
tients despite antiplatelet or anticoagulant treatment. TCD detection of mi
croemboli provides valuable pathophysiological information and may, therefo
re, improve current ischemic stroke subtype classification. Copyright (C) 2
000 S. Karger AG, Basel.