New insulin-mimetic zinc (II) complexes; Bis-maltolato zinc(II) and bis-2-hydroxypyridine-N-oxide zinc(II) with Zn(O-4) coordination mode

Authors
Yoshikawa, Y Ueda, E Kawabe, K Miyake, H Sakurai, H Kojima, Y
Citation
Y. Yoshikawa et al., New insulin-mimetic zinc (II) complexes; Bis-maltolato zinc(II) and bis-2-hydroxypyridine-N-oxide zinc(II) with Zn(O-4) coordination mode, CHEM LETT, (8), 2000, pp. 874-875
Citations number
10
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
8
Year of publication
2000
Pages
874 - 875
Database
ISI
SICI code
0366-7022(20000805):8<874:NIZ(CB>2.0.ZU;2-Q
Abstract
Zinc(II) complexes with a Zn(O-4) coordination mode were found to have insu linomimetic activity. A bis-maltolato zinc(II) (Zn(Mal)(2)) complex was rev ealed to be in an octahedral and a square pyramidal geometries in a unit fe ll. Both Zn(Mal)(2) (IC50 = 0.59 mM) and bis-2-hydroxypyridine-N-oxide zinc (II) (IC50 = 0.41 mM) complexes exhibited higher insulinomimetic activity t han VOSO4(IC50 = 1.00 mM) and ZnSO4(IC50 = 0.81 mM) in terms of IC50 values , which show 50% inhibition concentration of the complex in the free fatty acids release from rat adipocytes.