Biochemical markers of bone formation

Authors
Gundberg, CM
Citation
Cm. Gundberg, Biochemical markers of bone formation, CLIN LAB M, 20(3), 2000, pp. 489
Citations number
75
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
CLINICS IN LABORATORY MEDICINE
ISSN journal
02722712 → ACNP
Volume
20
Issue
3
Year of publication
2000
Database
ISI
SICI code
0272-2712(200009)20:3<489:BMOBF>2.0.ZU;2-9
Abstract
The biochemical markers of bone formation are comprised of products of oste oblastic synthesis. These include N- and C-propeptides of type I collagen, osteocalcin, and bone-specific alkaline phosphatase. This article reviews t he biochemistry and physiology of these markers. The various methods curren tly available for their determination are evaluated. Finally, the clinical use of these markers in the management of osteoporosis is discussed.