Lymphocyte signaling: Cbl sets the threshold for autoimmunity

Authors
Rudd, CE Schneider, H
Citation
Ce. Rudd et H. Schneider, Lymphocyte signaling: Cbl sets the threshold for autoimmunity, CURR BIOL, 10(9), 2000, pp. R344-R347
Citations number
21
Categorie Soggetti
Experimental Biology
Journal title
CURRENT BIOLOGY
ISSN journal
09609822 → ACNP
Volume
10
Issue
9
Year of publication
2000
Pages
R344 - R347
Database
ISI
SICI code
0960-9822(20000504)10:9<R344:LSCSTT>2.0.ZU;2-G
Abstract
CbI, a negative regulator of immune signaling, ha recently been shown to ac t as a ubiquitin-protein Further, two new papers describing Cbl-b-deficient mice suggest that CbI-b sets the threshold of signaling in T and B cells a nd prevents the development of autoimmunity.