Authors
Citation
Pm. Dunn, Fertility: Purinergic receptors and the male contraceptive pill, CURR BIOL, 10(8), 2000, pp. R305-R307
Citations number
12
Categorie Soggetti
Experimental Biology
Journal title
CURRENT BIOLOGY
ISSN journal
09609822
→ ACNP
Volume
10
Issue
8
Year of publication
2000
Pages
R305 - R307
Database
ISI
SICI code
0960-9822(20000420)10:8<R305:FPRATM>2.0.ZU;2-U
Abstract
Knockout mice lacking the P2X(1) receptor appear normal, but fail to breed.
Analysis of these mutant mice clearly shows that purinergic co-transmissio
n has a physiological role in the vas deferens. These findings also raise t
he possibility of developing non-hormonal ways of regulating male fertility
.