Efficient de novo folding of actins and tubulins requires two molecular cha
perones, the chaperonin TRiC (or CCT) and its novel cofactor GimC (or prefo
ldin). Recent studies indicate that TRiC is exquisitely adapted for this ta
sk, yet has the ability to interact with and assist the folding of numerous
other cellular proteins. (C) 2000 Elsevier Science Ltd. All rights reserve
d.