Blood coagulation: The outstanding hydrophobic residues

Authors
Pellequer, JL Gale, AJ Getzoff, ED
Citation
Jl. Pellequer et al., Blood coagulation: The outstanding hydrophobic residues, CURR BIOL, 10(6), 2000, pp. R237-R240
Citations number
17
Categorie Soggetti
Experimental Biology
Journal title
CURRENT BIOLOGY
ISSN journal
09609822 → ACNP
Volume
10
Issue
6
Year of publication
2000
Pages
R237 - R240
Database
ISI
SICI code
0960-9822(20000323)10:6<R237:BCTOHR>2.0.ZU;2-K
Abstract
Newly determined crystal structures suggest that the membrane-binding C2 do mains of blood coagulation cofactors Va and VIlla bind anionic phospholipid s through protruding solvent-exposed hydrophobic residues, aided by a crown of positively charged residues and by specific hydrogen-bonding side chain s. (C) 2000 Elsevier Science Ltd. All rights reserved.