Transition metal-mediated kinetic resolution

The number of asymmetric transformations catalyzed by chiral transition met al complexes is growing exponentially. With this growth, application to kin etic resolution processes is also blossoming. These include metal salen com plexes for epoxide opening, reductions, and recent examples of Sharpless ox idation methods. Great strides have been made in Zr-catalyzed carbon-carbon bond formations and Mo-catalyzed olefin metathesis. New Fe-based nucleophi lic catalysts allow for the resolution of a wide range of secondary alcohol s. Palladium-catalyzed asymmetric allylic substitution has most recently ap peared on the scene with outstanding levels of efficiency for kinetic and d ynamic kinetic resolution. This review presents an overview of new developm ents in transition metal-mediated kinetic resolution from the last two year s.