DIAGNOSIS AND MANAGEMENT OF A MALIGNANT GRANULOSA-CELL TUMOR IN A HOLSTEIN NULLIGRAVIDA - A CASE-STUDY

Transrectal palpation of an 18-mo-old, anestrous Holstein nulligravida revealed an enlarged left ovary. Ultrasonographically, the mass resem bled known equine granulosa cell tumor (GCT) images, Slowly, virilism developed. Fifty-five days after initial diagnosis, unilateral ovariec tomy was performed. The presurgical serum concentration of testosteron e was equal to that of a mature bull. During the 3 mo period following surgery, estrus expression resumed, the serum testosterone concentrat ion returned to baseline, and the heifer was diagnosed pregnant follow ing AI. A low grade, malignant GCT was the final histopathologically d iagnosis, Clinical diagnosis of GCT should involve ultrasonography and steroid hormone assay. image, similar to the one shown, may be charac teristic of GCT in the bovine. (C) 1997 by Elsevier Science Inc.