Relation of serum total sialic acid concentrations with diabetic complications and cardiovascular risk factors in Kuwaiti Type 2 diabetic patients

Serum total sialic acid is a marker of the acute phase response. Elevated l evels have also been associated with cardiovascular disease in the general Caucasian population and especially in Type 2 diabetic subjects. The purpos e of this study was to estimate serum total sialic acid concentrations amon g Kuwaiti Type 2 diabetic subjects and to investigate its association with macro and microvascular diabetes-related complications in that population. Serum total sialic acid levels were estimated by an enzymatic spectro-photo metric assay in two groups of subjects: (i) 358 Kuwaiti Type 2 diabetics (1 56 men and 202 women) referred for their annual evaluation to the specialis ed diabetic clinic at the main university teaching hospital in Kuwait, and (ii) 47 healthy age and sex matched non-diabetic Kuwaiti control population (13 men and 34 women). Serum sialic acid levels were significantly higher (P < 0.001) among the diabetic patients (mean +/- S.D.) (81.2 +/- 13.2 mg/d l) compared to the non-diabetic controls (66.9 +/- 11.0 mg/dl). Kuwaiti dia betic women had significantly higher concentrations compared to diabetic me n (85.2 +/- 12.1 vs. 75.9 +/- 13.0 mg/dl, P < 0.001). Among the controls th ere was no significant gender difference in sialic acid levels of women, (6 8.3 +/- 11.6 mg/dl) versus men (63.2 +/- 8.2 mg/dl). The gender difference in the diabetic patients was unrelated to the degree of obesity. Significan t correlations were found between serum total sialic acid concentrations an d such cardiovascular risk factors as plasma levels of apolipoprotein B, lo w density lipoprotein cholesterol, triglycerides and uric acid in the diabe tic subjects. Furthermore, thc re was a significant elevation in serum tota l sialic acid concentrations with increasing urinary albumin excretion, P < 0.001, but not with retinopathy or neuropathy. (C) 2000 Elsevier Science I reland Ltd. All rights reserved.