F. Altintas et al., Lidocaine 10% in the endotracheal tube cuff: blood concentrations, haemodynamic and clinical effects, EUR J ANAES, 17(7), 2000, pp. 436-442
The purpose of this study was to evaluate the effects (common haemodynamic
variables, peak cuff pressures, the incidence of reaction ('bucking') durin
g extubation and the incidence of sore throat after operation) of lidocaine
10% instilled into the endotracheal tube cuff in intubated patients. Plasm
a concentrations of lidocaine were assayed. Seventy ASA class I-II patients
scheduled for plastic surgery were studied. Patients were randomly divided
in two groups: the cuff of the endotracheal tube was inflated with either
lidocaine 10% (group L) or with saline (group S) immediately after endotrac
heal intubation. In group L patients, the haemodynamic changes were less (P
< 0.05), and the peak cuff pressure was lower (P < 0.01) than for group S.
At extubation, more patients reacted ('bucked') in group S (70.5% vs. 19.4
%, P < 0.01). The incidence and severity of sore throat were significantly
lower in group L 1 and 24-h after extubation. Plasma lidocaine concentratio
ns did nor reach toxic values. Lidocaine 10%, compared with saline, in the
endotracheal tube cuff was associated with less disturbance of haemodynamic
responses and less incidence of bucking during tracheal extubation. Lidoca
ine was also effective in reducing of incidence and severity of sore throat
after operation.