Mole maker phenotype: possible narrowing of the candidate region

Authors
Sensi, A Gualandi, F Pittalis, MC Calabrese, O Falciano, F Maestri, I Bovicelli, L Calzolari, E
Citation
A. Sensi et al., Mole maker phenotype: possible narrowing of the candidate region, EUR J HUM G, 8(8), 2000, pp. 641-644
Citations number
17
Categorie Soggetti
Molecular Biology & Genetics
Journal title
EUROPEAN JOURNAL OF HUMAN GENETICS
ISSN journal
10184813 → ACNP
Volume
8
Issue
8
Year of publication
2000
Pages
641 - 644
Database
ISI
SICI code
1018-4813(200008)8:8<641:MMPPNO>2.0.ZU;2-G
Abstract
Recent data has suggested that familial recurrent hydatidiform mole is a ra re autosomal recessive trait in women experiencing this gestational disease (MIM 231090). Here we provide molecular data on an additional family confi rming that recurrent familial hydatidiform moles are diploid, biparental an d arise from independent conceptions. A narrowing of the gene interval on c hromosome 19q13.3-13.4 is suggested by haplotype analysis in two sisters.