Recent developments and future directions in computational genomics

Computational genomics is a subfield of computational biology that deals wi th the analysis of entire genome sequences. Transcending the boundaries of classical sequence analysis, computational genomics exploits the inherent p roperties of entire genomes by modelling them as systems. We review recent developments in the field, discuss in some detail a number of novel approac hes that take into account the genomic context and argue that progress will be made by novel knowledge representation and simulation technologies. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier S cience B.V. All rights reserved.