Photodynamic laser therapy of the cervix

Photodynamic therapy has been proposed for the treatment of HPV induced dys plasia of the cervix uteri as it has the potential of normalisation without loss of functional tissue as well as virusdevitalisation. A new light diff user for homogeneous irradiation of the complete cervical surface was evalu ated during an open pilot study. The design incorporates a cylindric (intra cervical) and spheric: (surface of portio) shape. During an outpatient proc edure laser irradiation with less than or equal to 150 mW/cm(2) was perform ed utilizing a Dye laser at 635 nm. 70 patients with suspect PAP smear were included in this study. Laser irradiation was performed 4 hours after topi cal application of 10% ALA solution. Reevaluation verified a normalisation of the cytologic results and implicated a PDT induced virusdevitalisation i n 9 out of 70 cases.