Endometrial metastasis from breast cancer in a patient receiving tamoxifentherapy

Tamoxifen (TAM) is known to be associated with several types of endometrial pathologies, e,g, hyperplasias, polyps and endometrial carcinomas, sometim es of special histologic type. Here we report a rare case of endometrial me tastasis from a breast carcinoma (ductal carcinoma) discovered during TAM t herapy. This occurrence does not suggest that TAM treatment causes endometr ial metastases of breast cancer. However, clinicians should be aware of thi s possibility and provide patients receiving TAM therapy with close gynecol ogic follow-up using liberal indications for endometrial biopsies. Copyrigh t (C) 2000 S. Karger AG, Basel.