Intralesional methotrexate injection. An effective time- and cost-saving therapy alternative in Keratoacanthomas that are difficult to treat operatively

A 53 year old female patient developed a keratoacanthoma, present on the le ft side of her nose for two months. After repeated unsuccessful trials with cryotherapy, she was treated with intralesional injection of methotrexate performed twice with a weekly internal. This led to complete resolution wit hin 5 weeks. Although controlled studies on the effect of methotrexate in k eratoacanthoma are not available, the rapid regression and the good cosmeti c result suggest that this therapy may play a beneficial role in treating t hese lesions especially in problem locations.